#Proteasome

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Neuronal‐specific #proteasome augmentation extends #lifespan and reduces age‐related cognitive decline in flies. This is specific to the nervous system since ubiquitous proteasome overexpression was detrimental to some healthspan measures

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Higginsiannin B inhibits both chymotrypsin and caspase catalytic activities of the #proteasome

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#theustunlab is present at #ICMPMI2019 with 2 posters:@PaulGoug (572-P2) will present how pseudomonas mediates the crosstalk btw trafficking & #autophagy and @LanginGautier (806-P2) will present how a NAC TF pair controls #proteasome regulation during immunity

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SY40: #Symposium 40 - The aging brain: mechanisms and interventions, organized by Dan Ehninger & Selma Kanazir. #FRM2019 #aging #proteasome #memorytraining

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New Special Issue "Role of Nrf2 in Disease: Novel Molecular Mechanisms and Therapeutic Approaches" by Prof. Isabel Lastres-Becker @isalabe13 @UAM_Madrid
✏️Open for submissions
🗓️31 March 2020
#inflammation #autophagy #proteasome #proteostasis #oxidativestress #neurodegeneration

New Special Issue "Role of Nrf2 in Disease: Novel Molecular Mechanisms and Therapeutic Approaches" by Prof. Isabel Lastres-Becker @isalabe13 @UAM_Madrid ✏️Open for submissions 🗓️31 March 2020 #inflammation #autophagy #proteasome #proteostasis #oxidativestress #neurodegeneration

Incredible structures and biological insights into #proteasome function- beautiful science!! #cryoEM

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TOMORROW: 
Ubiquitin signalling in immunity and vesicle trafficking 🌱 
By @TrujilloLab from @UniFreiburg 
🗓️July 4th, 15:00h at @CRAGENOMICA Barcelona 
https://www.cragenomica.es/events/ubiquitin-signalling-immunity-and-vesicle-trafficking …
Find more about his work at http://trujillolab.com/publications/  - #ubiquitination, 26S #proteasome, #UBIGate

TOMORROW: Ubiquitin signalling in immunity and vesicle trafficking 🌱 By @TrujilloLab from @UniFreiburg 🗓️July 4th, 15:00h at @CRAGENOMICA Barcelona https://www.cragenomica.es/events/ubiquitin-signalling-immunity-and-vesicle-trafficking … Find more about his work at http://trujillolab.com/publications/  - #ubiquitination, 26S #proteasome, #UBIGate

Fantastic @MRC_IGMM talk by @MSCActions fellow & @FryLab alum Suzy Prosser from @laurpelletier lab- 'Emerging role for centrosomal proteins in regulation of proteostasis'! Amazing intersection of hot fields: #centriolarsatellites #ubiquitin #centrioles #autophagy & #proteasome!

Fantastic @MRC_IGMM talk by @MSCActions fellow & @FryLab alum Suzy Prosser from @laurpelletier lab- 'Emerging role for centrosomal proteins in regulation of proteostasis'! Amazing intersection of hot fields: #centriolarsatellites #ubiquitin #centrioles #autophagy & #proteasome!

The first #ubiquitin blot from our practical course „proteolytic degradation pathways“@ZMBP_Tuebingen .Students did a great job so far and also generated new results! It‘s fun to teach about #autophagy #proteasome #happyPI #teaching #proteostasis

The first #ubiquitin blot from our practical course „proteolytic degradation pathways“@ZMBP_Tuebingen .Students did a great job so far and also generated new results! It‘s fun to teach about #autophagy #proteasome #happyPI #teaching #proteostasis

Prospective Study of Cardiac Events During #Proteasome Inhibitor Therapy for Relapsed Multiple #Myeloma #mmsm

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Strategic Advancements in #Drug #Development are Beholding the #Growthof #Proteasome #Inhibitors #Pipeline
Download the research report at: http://bit.ly/2WLLJZk 

Strategic Advancements in #Drug #Development are Beholding the #Growthof #Proteasome #Inhibitors #Pipeline Download the research report at: http://bit.ly/2WLLJZk 

Check out the talks by our fantastic speaker line-up 📢 in the updated program for #PPStasis_2019 🌱🍂🍀 http://plantproteostasis2019.com/program/  #proteostasis #PlantSci #ubiquitin #SUMO #proteasome #autophagy #nendrule #degron #VesicleTraffic

Check out the talks by our fantastic speaker line-up 📢 in the updated program for #PPStasis_2019 🌱🍂🍀 http://plantproteostasis2019.com/program/  #proteostasis #PlantSci #ubiquitin #SUMO #proteasome #autophagy #nendrule #degron #VesicleTraffic

Faculty fellow @Stanford_ChEMH @mbogyo and collaborators have found selective #proteasome inhibitors that show promise for treating drug-resistant #malaria @PLOSPathogens @StanfordPath

Faculty fellow @Stanford_ChEMH @mbogyo and collaborators have found selective #proteasome inhibitors that show promise for treating drug-resistant #malaria @PLOSPathogens @StanfordPath

The #proteasome as a target: How not tidying up can have toxic consequences for parasitic protozoa https://www.pnas.org/content/116/21/10198 … #Protists By Elizabeth Winzeler and Sabine Ottilie

The #proteasome as a target: How not tidying up can have toxic consequences for parasitic protozoa https://www.pnas.org/content/116/21/10198 … #Protists By Elizabeth Winzeler and Sabine Ottilie

Strategic Advancements in #Drug #Development are Beholding the #Growth of #Proteasome #Inhibitors #Pipeline
Get the research copy at: http://bit.ly/2WLLJZk 

Strategic Advancements in #Drug #Development are Beholding the #Growth of #Proteasome #Inhibitors #Pipeline Get the research copy at: http://bit.ly/2WLLJZk 

Covalent #Plasmodium falciparum-selective #proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents: Barbara Stokes et al.  https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1007722 … #malaria #protists

Covalent #Plasmodium falciparum-selective #proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents: Barbara Stokes et al. https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1007722 … #malaria #protists

Quoted @jaybradner

Happy anniversary to GNF! Can’t wait to see what the next 20 years of innovation holds. #GNF20Anniv https://twitter.com/NovartisScience/status/1135531581634801664 …

@jaybradner, proud to have been among the first 100 employees. What exciting years! #PROTACs #Proteasome #MedChem #Pharma #DrugDiscovery

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